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Second-generation antipsychotics are often preferred over first-generation antipsychotics primarily because they tend to cause fewer movement disorders, which are known as extrapyramidal symptoms (EPS). These symptoms can include tremors, rigidity, and tardive dyskinesia, which are significant concerns with first-generation antipsychotics. The mechanism of action in second-generation antipsychotics allows them to be effective in treating psychosis while minimizing these side effects, making them more tolerable for patients.

While second-generation antipsychotics can also have other advantages, such as a different side effect profile that may include less sedation and fewer overall side effects, the key distinguishing factor recognized in many clinical settings is their lower incidence of movement disorders. This improvement greatly enhances the quality of life for individuals requiring treatment for schizophrenia and other mental health conditions, leading to a broader acceptance and usage of these medications over their first-generation counterparts.